{
    "resourceType": "Evidence",
    "extension": [
        {
            "url": "https://treatments.telix.health/implementationguide/extensions/study-country",
            "valueCodeableConcept": {
                "coding": [
                    {
                        "system": "https://hl7.org/fhir/ValueSet/country",
                        "code": "BR",
                        "display": "Brazil"
                    },
                    {
                        "system": "https://hl7.org/fhir/ValueSet/country",
                        "code": "CN",
                        "display": "China"
                    },
                    {
                        "system": "https://hl7.org/fhir/ValueSet/country",
                        "code": "DE",
                        "display": "Germany"
                    },
                    {
                        "system": "https://hl7.org/fhir/ValueSet/country",
                        "code": "IT",
                        "display": "Italy"
                    },
                    {
                        "system": "https://hl7.org/fhir/ValueSet/country",
                        "code": "GB",
                        "display": "United Kingdom"
                    }
                ]
            }
        }
    ],
    "identifier": [
        {
            "use": "official",
            "system": "https://interneb.org/global-computable-evidence-identifiers",
            "value": "migraine-placebo-10.1002-14651858-cd001218-pub3"
        }
    ],
    "title": "This Evidence resource describes the placebo comparator used in a study evaluating acupuncture for the prevention of episodic migraine.",
    "status": "active",
    "date": "2016-06",
    "publisher": "Linca Telecomunicações Ltda",
    "author": [
        {
            "name": "Diuary Cordeiro Machado",
            "telecom": [
                {
                    "system": "email",
                    "value": "diuarycm@gmail.com"
                }
            ]
        }
    ],
    "classification": [
        {
            "code": {
                "system": "https://build.fhir.org/ig/HL7/ebm/en/ValueSet-179431.html",
                "code": "population",
                "display": "Population"
            },
            "valueCodeableConcept": {
                "coding": [
                    {
                        "system": "https://icd.who.int/ct/icd11_mms/en",
                        "version": "2026-01",
                        "code": "8A80",
                        "display": "Migraine"
                    }
                ]
            }
        },
        {
            "code": {
                "system": "https://build.fhir.org/ig/HL7/ebm/en/ValueSet-179431.html",
                "code": "comparator",
                "display": "Comparator"
            },
            "valueCodeableConcept": {
                "coding": [
                    {
                        "system": "https://atcddd.fhi.no/atc_ddd_index/",
                        "code": "V03AX10",
                        "display": "Placebo"
                    }
                ]
            }
        },
        {
            "code": {
                "system": "https://build.fhir.org/ig/HL7/ebm/en/ValueSet-179431.html",
                "code": "outcome-measure",
                "display": "Outcome Measure"
            },
            "valueCodeableConcept": {
                "coding": [
                    {
                        "system": "https://terminology.hl7.org/7.1.0/en/ValueSet-research-study-purpose-type.html",
                        "code": "efficacy",
                        "display": "Efficacy Study"
                    }
                ]
            }
        }
    ],
    "relatesTo": [
        {
            "type": {
                "coding": [
                    {
                        "system": "https://terminology.hl7.org/7.1.0/en/CodeSystem-artifact-relationship-type.html",
                        "code": "citation",
                        "display": "Citation"
                    }
                ]
            },
            "targetUri": "https://doi.org/10.1002/14651858.CD001218.pub3"
        }
    ],
    "description": "Klaus Linde et al. Cochrane Database of Systematic Reviews, 06 / 2016",
    "assertion": "Placebo comparator for acupuncture in the prevention of episodic migraine",
    "variableDefinition": [
        {
            "variableRole": "outcome",
            "coding": [
                {
                    "system": "https://build.fhir.org/valueset-variable-role.html",
                    "code": "outcome",
                    "display": "Outcome"
                }
            ]
        }
    ],
    "studyDesign": [
        {
            "coding": [
                {
                    "system": "https://hl7.org/fhir/codesystem-study-design.html",
                    "code": "synthesis-type",
                    "display": "Systematic Review and Meta-Analysis"
                }
            ]
        }
    ],
    "statistic": [
        {
            "description": "Efficacy calculated based on participants who achieved at least a 50% reduction in headache frequency in the sham acupuncture comparator group.",
            "category": {
                "coding": [
                    {
                        "system": "https://treatments.telix.health/codesystem/categorized-efficacy-outcomes",
                        "code": "persistent reduction of symptoms",
                        "display": "Persistent reduction of symptoms"
                    }
                ]
            },
            "numberOfEvents": 770,
            "numberAffected": 314,
            "sampleSize": {
                "numberOfParticipants": 1825
            }
        }
    ]
}