{
  "resourceType": "Evidence",
  "extension": [
    {
      "url": "https://treatments.telix.health/implementationguide/extensions/study-country",
      "valueCodeableConcept": {
        "coding": [
          {
            "system": "https://hl7.org/fhir/ValueSet/country",
            "code": "BR",
            "display": "Brazil"
          },
          {
            "system": "https://hl7.org/fhir/ValueSet/country",
            "code": "CN",
            "display": "China"
          },
          {
            "system": "https://hl7.org/fhir/ValueSet/country",
            "code": "DE",
            "display": "Germany"
          },
          {
            "system": "https://hl7.org/fhir/ValueSet/country",
            "code": "IT",
            "display": "Italy"
          },
          {
            "system": "https://hl7.org/fhir/ValueSet/country",
            "code": "GB",
            "display": "United Kingdom"
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      }
    }
  ],
  "identifier": [
    {
      "use": "official",
      "system": "https://interneb.org/global-computable-evidence-identifiers",
      "value": "migraine-placebo-10.1002-14651858-cd001218-pub3"
    }
  ],
  "title": "This Evidence resource describes the placebo comparator used in a study evaluating acupuncture for the prevention of episodic migraine.",
  "status": "active",
  "date": "2016-06",
  "publisher": "Linca Telecomunicações Ltda",
  "author": [
    {
      "name": "Diuary Cordeiro Machado",
      "telecom": [
        {
          "system": "email",
          "value": "diuarycm@gmail.com"
        }
      ]
    }
  ],
  "classification": [
    {
      "code": {
        "system": "https://build.fhir.org/ig/HL7/ebm/en/ValueSet-179431.html",
        "code": "population",
        "display": "Population"
      },
      "valueCodeableConcept": {
        "coding": [
          {
            "system": "https://icd.who.int/ct/icd11_mms/en",
            "version": "2026-01",
            "code": "8A80",
            "display": "Migraine"
          }
        ]
      }
    },
    {
      "code": {
        "system": "https://build.fhir.org/ig/HL7/ebm/en/ValueSet-179431.html",
        "code": "comparator",
        "display": "Comparator"
      },
      "valueCodeableConcept": {
        "coding": [
          {
            "system": "https://atcddd.fhi.no/atc_ddd_index/",
            "code": "V03AX10",
            "display": "Placebo"
          }
        ]
      }
    },
    {
      "code": {
        "system": "https://build.fhir.org/ig/HL7/ebm/en/ValueSet-179431.html",
        "code": "outcome-measure",
        "display": "Outcome Measure"
      },
      "valueCodeableConcept": {
        "coding": [
          {
            "system": "https://terminology.hl7.org/7.1.0/en/ValueSet-research-study-purpose-type.html",
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    }
  ],
  "relatesTo": [
    {
      "type": {
        "coding": [
          {
            "system": "https://terminology.hl7.org/7.1.0/en/CodeSystem-artifact-relationship-type.html",
            "code": "citation",
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        ]
      },
      "targetUri": "https://doi.org/10.1002/14651858.CD001218.pub3"
    }
  ],
  "description": "Klaus Linde et al. Cochrane Database of Systematic Reviews, 06 / 2016",
  "assertion": "Placebo comparator for acupuncture in the prevention of episodic migraine",
  "variableDefinition": [
    {
      "variableRole": "outcome",
      "coding": [
        {
          "system": "https://build.fhir.org/valueset-variable-role.html",
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      ]
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  ],
  "studyDesign": [
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      "coding": [
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          "system": "https://hl7.org/fhir/codesystem-study-design.html",
          "code": "synthesis-type",
          "display": "Systematic Review and Meta-Analysis"
        }
      ]
    }
  ],
  "statistic": [
    {
      "description": "Efficacy calculated based on participants who achieved at least a 50% reduction in headache frequency in the sham acupuncture comparator group.",
      "category": {
        "coding": [
          {
            "system": "https://treatments.telix.health/codesystem/categorized-efficacy-outcomes",
            "code": "persistent reduction of symptoms",
            "display": "Persistent reduction of symptoms"
          }
        ]
      },
      "numberOfEvents": 770,
      "numberAffected": 314,
      "sampleSize": {
        "numberOfParticipants": 1825
      }
    }
  ]
}